Pyruvic acid before combining with oxaloacetic acid of citric acid cycle becomes

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UP TGT Biology 2010 Official Paper
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  1. Lactic acid
  2. Aceto-acetic
  3. Cis-acotinic acid
  4. Acetyl Co-A

Answer (Detailed Solution Below)

Option 4 : Acetyl Co-A
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Explanation:

  • Pyruvate or pyruvic acid, which is formed by the glycolytic catabolism of carbohydrates in the cytosol, after it enters the mitochondrial matrix undergoes oxidative decarboxylation by a complex set of reactions catalyzed by pyruvic dehydrogenase.
  • The reactions catalyzed by pyruvic dehydrogenase require the participation of several coenzymes, including NAD+ and Coenzyme A. This process is called Link reaction or gateway reaction.
  • During this process, two molecules of NADH are produced from the metabolism of two molecules of pyruvic acid (produced from one glucose molecule during glycolysis)
  • The acetyl CoA then enters a cyclic pathway, the citric acid cycle more commonly called Krebs’ cycle after the scientist Hans Krebs who first elucidated it.

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  • Thus, Pyruvic acid before combining with oxaloacetic acid of the citric acid cycle becomes Acetyl CoA

Additional Information

  • Under anaerobic conditions, the pyruvic acid undergoes partial oxidation to form lactic acid. This process is catalyzed by the enzyme lactate dehydrogenase
  • During the Kreb's cycle, Acetyl CoA condenses with Oxaloacetic acid to form Citric acid. This Citric acid is then converted into Cis Aconitic acid in the presence of enzyme Aconitase.
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